Colon is the second largest cause for death in the U.S. This disease is caused by the genetic mutations that typically accumulate over the course of a decade. Colorectal cancer develops from uncontrolled growth and survival of abnormal cells in the colon or rectum, which are the final sections of the digestive, or gastrointestinal, tract.
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Do Oral Bacteria Cause Colorectal Cancer?
Most probably everyone will have a doubt on “Do oral bacteria cause colorectal cancer?”. To explore more, in this article I’ll help you to find out more about it and also the relation between oral bacteria and colorectal cancer. Read on.
What is Colorectal Cancer?
Colorectal cancer is also known as bowel cancer, rectal cancer or colon cancer, which any cancer that affect colon and rectal. It is the second leading death in women and third for men, but the American cancer society estimate that 1in 21 men and 1 in 23 women in the United States will develop colorectal cancer during their lifetime. Due to the treatments and screening techniques, the death rate of colorectal cancer has been falling.
Major Symptoms of Colorectal Cancer
The major symptoms also indicate other possible condition, so it is important to see a doctor if symptoms persist for 4 weeks or more. The major Symptoms of colorectal cancer include:
- Changes in bowel habits.
- Diarrhea or Constipation
- A feeling that the bowel does not empty properly after a bowel movement.
- Blood in feces that makes stool looks black.
- Bright red blood coming from the rectum.
- Pain and bloating in the abdomen.
- Unexplained weight loss.
- A feeling of fullness in the abdomen, even after not eating for a while.
- Fatigue or Tiredness.
- A lump in the abdomen or the back passage felt by your doctor.
- Unexplained iron deficiency in men, or in women after menopause.
Role of Oral bacteria in Colorectal Cancer
Researchers at the Columbia University College of Dental Medicine have determined how F. nucleatum, a common oral bacteria often implicated in tooth decay accelerates the growth of colon cancer. From the current study, the researcher found that in cell cultures that noncancerous colon cells lack a protein, called Annexin A1, which stimulates cancer growth. They then confirmed both in vitro and later in mice that disabling Annexin A1 prevented F. nucleatum from binding to the cancer cells, slowing their growth. And also, the researcher has found that F. nucleatum increases the production of Annexin A1, attracting more of the bacteria.
Treatment
The treatment includes the size, location and the stage of cancer so it will depend on several factors. Major treatment option includes surgery, chemotherapy, and radiotherapy.
- Surgery
It is the most common treatment, to reduce the risk of cancer spreading the affected malignant tumors and any nearby lymph nodes will be removed. If the cancer is diagnosed early enough, surgery may successfully remove it. If surgery does not stop cancer, it will ease the symptoms.
- Chemotherapy
It involves using medicine or chemical to destroy the cancerous cells. It is commonly used for colon cancer treatment. This is a kind of chemotherapy that specifically targets the proteins that encourage the development of some cancers. They may have fewer side effects than other types of chemotherapy.
- Radiotherapy
Radiation therapy uses high energy radiation beams to destroy the cancer cells and to prevent them from multiplying. This is more commonly used for rectal cancer treatment. It may be used before surgery in an attempt to shrink the tumor. Both radiation therapy and chemotherapy may be given after surgery to help lower the chances of recurrence.
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